HTRA2

HtrA serine peptidase 2 | OMI, PARK13, PRSS25

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Member of: DE-1

Biological processes 78 terms

CD40 receptor complex (GO:0035631)CD40 receptor complex (GO:0035631)cellular response to growth factor stimulus (GO:0071363)cellular response to heat (GO:0034605)cellular response to interferon-beta (GO:0035458)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cellular response to retinoic acid (GO:0071300)chromatin (GO:0000785)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytoskeleton (GO:0005856)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)execution phase of apoptosis (GO:0097194)identical protein binding (GO:0042802)intracellular signal transduction (GO:0035556)intrinsic apoptotic signaling pathway (GO:0097193)intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)membrane (GO:0016020)membrane (GO:0016020)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial membrane (GO:0031966)mitochondrial protein catabolic process (GO:0035694)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)negative regulation of cell cycle (GO:0045786)negative regulation of neuron apoptotic process (GO:0043524)negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)negative regulation of type 2 mitophagy (GO:1905090)neuron apoptotic process (GO:0051402)nucleus (GO:0005634)peptidase activity (GO:0008233)peptidase activity (GO:0008233)peptidase activity (GO:0008233)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of execution phase of apoptosis (GO:1900119)positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)positive regulation of protein localization to mitochondrion (GO:1903749)programmed cell death (GO:0012501)protein autoprocessing (GO:0016540)protein binding (GO:0005515)protein catabolic process (GO:0030163)protein serine/threonine kinase inhibitor activity (GO:0030291)protein-containing complex (GO:0032991)proteolysis (GO:0006508)proteolysis (GO:0006508)proteolysis (GO:0006508)proteolysis (GO:0006508)regulation of autophagy of mitochondrion (GO:1903146)regulation of autophagy of mitochondrion (GO:1903146)response to herbicide (GO:0009635)serine-type endopeptidase activity (GO:0004252)serine-type endopeptidase activity (GO:0004252)serine-type endopeptidase activity (GO:0004252)serine-type endopeptidase activity (GO:0004252)serine-type endopeptidase activity (GO:0004252)serine-type endopeptidase complex (GO:1905370)serine-type peptidase activity (GO:0008236)serine-type peptidase activity (GO:0008236)serine-type peptidase activity (GO:0008236)ubiquitin ligase inhibitor activity (GO:1990948)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating HTRA2 0 TFs

Transcription factors with Perturb-seq knockdown data for HTRA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HTRA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HTRA2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HTRA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:74,261,293–74,261,813	268.3 kb	Distal (>10kb) Multiome	184
chr2:74,374,253–74,375,246	155.2 kb	Distal (>10kb) Multiome	158
chr2:74,379,653–74,380,438	149.9 kb	Distal (>10kb) Multiome	229
chr2:74,391,129–74,392,484	138.0 kb	Distal (>10kb) Multiome	876
chr2:74,421,273–74,422,464	108.2 kb	Distal (>10kb) Multiome	756
chr2:74,426,172–74,426,842	103.3 kb	Distal (>10kb) Multiome	88
chr2:74,440,246–74,442,723	87.8 kb	Distal (>10kb) Multiome	1050
chr2:74,454,612–74,455,413	74.9 kb	Distal (>10kb) Multiome	982
chr2:74,457,177–74,459,169	71.7 kb	Distal (>10kb) Multiome	934
chr2:74,464,912–74,465,776	64.5 kb	Distal (>10kb) Multiome	842
chr2:74,472,106–74,473,059	57.3 kb	Distal (>10kb) Multiome	1071
chr2:74,481,955–74,483,673	46.8 kb	Distal (>10kb) Multiome HiCAR	1031
chr2:74,497,707–74,500,027	30.4 kb	Distal (>10kb) Multiome	553
chr2:74,502,724–74,504,160	26.7 kb	Distal (>10kb) Multiome	816
chr2:74,506,905–74,508,524	22.3 kb	Distal (>10kb) Multiome	1063
chr2:74,515,477–74,516,725	13.5 kb	Distal (>10kb) Multiome	262
chr2:74,526,271–74,526,489	3.4 kb	Proximal (<10kb)	376
chr2:74,529,210–74,530,815	90 bp	At TSS Multiome	988
chr2:74,548,706–74,549,795	19.5 kb	Distal (>10kb) Multiome	625
chr2:74,553,035–74,555,636	24.6 kb	Distal (>10kb) Multiome	768
chr2:74,647,804–74,648,489	118.3 kb	Distal (>10kb) Multiome	232
chr2:74,653,808–74,654,908	124.3 kb	Distal (>10kb) Multiome	658
chr2:74,715,073–74,715,890	185.4 kb	Distal (>10kb) Multiome	768
chr2:74,777,656–74,779,073	248.7 kb	Distal (>10kb) Multiome	426
chr2:74,816,374–74,817,201	286.9 kb	Distal (>10kb) Multiome	373
chr2:74,822,732–74,823,334	293.0 kb	Distal (>10kb) Multiome	40

Genome Browser

Genomic view of the HTRA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.