This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RTKN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RTKN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RTKN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,147,573–74,148,843 | 294.4 kb | Distal (>10kb) Multiome | 884 | |
| chr2:74,178,147–74,179,324 | 263.5 kb | Distal (>10kb) Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 254.2 kb | Distal (>10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 243.9 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:74,261,293–74,261,813 | 180.8 kb | Distal (>10kb) Multiome | 184 | |
| chr2:74,374,253–74,375,246 | 67.7 kb | Distal (>10kb) Multiome | 158 | |
| chr2:74,379,653–74,380,438 | 62.4 kb | Distal (>10kb) Multiome | 229 | |
| chr2:74,391,129–74,392,484 | 50.5 kb | Distal (>10kb) Multiome | 876 | |
| chr2:74,421,273–74,422,464 | 20.7 kb | Distal (>10kb) Multiome | 756 | |
| chr2:74,426,172–74,426,842 | 15.8 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,440,246–74,442,723 | 272 bp | At TSS Multiome | 1050 | |
| chr2:74,454,612–74,455,413 | 12.6 kb | Distal (>10kb) Multiome | 982 | |
| chr2:74,457,177–74,459,169 | 15.8 kb | Distal (>10kb) Multiome | 934 | |
| chr2:74,464,912–74,465,776 | 23.0 kb | Distal (>10kb) Multiome | 842 | |
| chr2:74,472,106–74,473,059 | 30.2 kb | Distal (>10kb) Multiome | 1071 | |
| chr2:74,481,955–74,483,673 | 40.7 kb | Distal (>10kb) Multiome | 1031 | |
| chr2:74,497,707–74,500,027 | 57.1 kb | Distal (>10kb) Multiome | 553 | |
| chr2:74,502,724–74,504,160 | 60.8 kb | Distal (>10kb) Multiome | 816 | |
| chr2:74,506,905–74,508,524 | 65.2 kb | Distal (>10kb) Multiome | 1063 | |
| chr2:74,515,477–74,516,725 | 74.0 kb | Distal (>10kb) Multiome | 262 | |
| chr2:74,529,210–74,530,815 | 87.4 kb | Distal (>10kb) Multiome | 988 | |
| chr2:74,548,706–74,549,795 | 107.0 kb | Distal (>10kb) Multiome | 625 | |
| chr2:74,553,035–74,555,636 | 112.1 kb | Distal (>10kb) Multiome | 768 | |
| chr2:74,647,804–74,648,489 | 205.8 kb | Distal (>10kb) Multiome | 232 | |
| chr2:74,653,808–74,654,908 | 211.8 kb | Distal (>10kb) Multiome | 658 | |
| chr2:74,715,073–74,715,890 | 272.9 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the RTKN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.