Enables protein homodimerization activity. Involved in negative regulation of receptor internalization; regulation of MAPK cascade; and regulation of epidermal growth factor receptor signaling pathway. Located in vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR54. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR54 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR54, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,147,573–74,148,843 | 273.7 kb | Distal (>10kb) Multiome | 884 | |
| chr2:74,178,147–74,179,324 | 242.8 kb | Distal (>10kb) Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 233.5 kb | Distal (>10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 223.2 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:74,261,293–74,261,813 | 160.1 kb | Distal (>10kb) Multiome | 184 | |
| chr2:74,374,253–74,375,246 | 47.0 kb | Distal (>10kb) Multiome | 158 | |
| chr2:74,379,653–74,380,438 | 41.7 kb | Distal (>10kb) Multiome | 229 | |
| chr2:74,391,129–74,392,484 | 29.8 kb | Distal (>10kb) Multiome | 876 | |
| chr2:74,421,273–74,422,464 | 17 bp | At TSS Multiome | 756 | |
| chr2:74,426,172–74,426,842 | 4.9 kb | Proximal (<10kb) Multiome | 88 | |
| chr2:74,440,246–74,442,723 | 20.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:74,454,612–74,455,413 | 33.3 kb | Distal (>10kb) Multiome | 982 | |
| chr2:74,457,177–74,459,169 | 36.5 kb | Distal (>10kb) Multiome | 934 | |
| chr2:74,464,912–74,465,776 | 43.7 kb | Distal (>10kb) Multiome | 842 | |
| chr2:74,472,106–74,473,059 | 50.9 kb | Distal (>10kb) Multiome | 1071 | |
| chr2:74,481,955–74,483,673 | 61.4 kb | Distal (>10kb) Multiome | 1031 | |
| chr2:74,497,707–74,500,027 | 77.8 kb | Distal (>10kb) Multiome | 553 | |
| chr2:74,502,724–74,504,160 | 81.5 kb | Distal (>10kb) Multiome | 816 | |
| chr2:74,506,905–74,508,524 | 85.9 kb | Distal (>10kb) Multiome | 1063 | |
| chr2:74,515,477–74,516,725 | 94.7 kb | Distal (>10kb) Multiome | 262 | |
| chr2:74,529,210–74,530,815 | 108.1 kb | Distal (>10kb) Multiome | 988 | |
| chr2:74,548,706–74,549,795 | 127.7 kb | Distal (>10kb) Multiome | 625 | |
| chr2:74,553,035–74,555,636 | 132.8 kb | Distal (>10kb) Multiome | 768 | |
| chr2:74,647,804–74,648,489 | 226.5 kb | Distal (>10kb) Multiome | 232 | |
| chr2:74,653,808–74,654,908 | 232.5 kb | Distal (>10kb) Multiome | 658 | |
| chr2:74,715,073–74,715,890 | 293.6 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the WDR54 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.