LOXL3
lysyl oxidase like 3

This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]

Developmental clusters: GC4
Biological processes 45 terms
animal organ development (GO:0048513)collagen fibril organization (GO:0030199)copper ion binding (GO:0005507)copper ion binding (GO:0005507)cytoplasm (GO:0005737)cytoplasm (GO:0005737)elastic fiber (GO:0071953)epithelial to mesenchymal transition (GO:0001837)extracellular matrix (GO:0031012)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)fibronectin binding (GO:0001968)fibronectin binding (GO:0001968)fibronectin fibril organization (GO:1905590)fibronectin fibril organization (GO:1905590)inflammatory response (GO:0006954)inflammatory response (GO:0006954)lung development (GO:0030324)lung development (GO:0030324)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of T-helper 17 cell lineage commitment (GO:2000329)negative regulation of T-helper 17 cell lineage commitment (GO:2000329)negative regulation of T-helper 17 cell lineage commitment (GO:2000329)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor (GO:0016641)peptidyl-lysine oxidation (GO:0018057)positive regulation of integrin-mediated signaling pathway (GO:2001046)positive regulation of integrin-mediated signaling pathway (GO:2001046)protein binding (GO:0005515)protein-lysine 6-oxidase activity (GO:0004720)protein-lysine 6-oxidase activity (GO:0004720)protein-lysine 6-oxidase activity (GO:0004720)protein-lysine 6-oxidase activity (GO:0004720)roof of mouth development (GO:0060021)roof of mouth development (GO:0060021)somite development (GO:0061053)somite development (GO:0061053)spinal cord development (GO:0021510)spinal cord development (GO:0021510)tissue development (GO:0009888)
Expression (TPM)
LOXL3 — as a Regulated Gene

TFs regulating LOXL3 0 TFs

Transcription factors with Perturb-seq knockdown data for LOXL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LOXL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to LOXL3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LOXL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:74,261,293–74,261,813 292.3 kb Distal (>10kb) Multiome 184
chr2:74,374,253–74,375,246 179.2 kb Distal (>10kb) Multiome 158
chr2:74,379,653–74,380,438 173.9 kb Distal (>10kb) Multiome 229
chr2:74,391,129–74,392,484 162.0 kb Distal (>10kb) Multiome 876
chr2:74,421,273–74,422,464 132.2 kb Distal (>10kb) Multiome 756
chr2:74,426,172–74,426,842 127.4 kb Distal (>10kb) Multiome 88
chr2:74,440,246–74,442,723 111.8 kb Distal (>10kb) Multiome 1050
chr2:74,454,612–74,455,413 99.0 kb Distal (>10kb) Multiome 982
chr2:74,457,177–74,459,169 95.7 kb Distal (>10kb) Multiome 934
chr2:74,464,912–74,465,776 88.6 kb Distal (>10kb) Multiome 842
chr2:74,472,106–74,473,059 81.3 kb Distal (>10kb) Multiome 1071
chr2:74,481,955–74,483,673 70.8 kb Distal (>10kb) Multiome 1031
chr2:74,497,707–74,500,027 54.5 kb Distal (>10kb) Multiome 553
chr2:74,502,724–74,504,160 50.7 kb Distal (>10kb) Multiome 816
chr2:74,506,905–74,508,524 46.3 kb Distal (>10kb) Multiome 1063
chr2:74,515,477–74,516,725 37.5 kb Distal (>10kb) Multiome 262
chr2:74,529,210–74,530,815 24.1 kb Distal (>10kb) Multiome 988
chr2:74,548,706–74,549,795 4.5 kb Proximal (<10kb) Multiome 625
chr2:74,553,035–74,555,636 582 bp At TSS Multiome 768
chr2:74,647,804–74,648,489 94.3 kb Distal (>10kb) Multiome 232
chr2:74,653,808–74,654,908 100.3 kb Distal (>10kb) Multiome 658
chr2:74,715,073–74,715,890 161.4 kb Distal (>10kb) Multiome 768
chr2:74,777,656–74,779,073 224.7 kb Distal (>10kb) Multiome 426
chr2:74,816,374–74,817,201 262.9 kb Distal (>10kb) Multiome 373
chr2:74,822,732–74,823,334 269.0 kb Distal (>10kb) Multiome 40
chr2:74,833,573–74,835,838 281.4 kb Distal (>10kb) Multiome 968

Genome Browser

Genomic view of the LOXL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:74,251,293 – 74,845,838
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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