The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for MOB1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOB1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOB1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:73,921,096–73,921,666 | 257.5 kb | Distal (>10kb) Multiome | 284 | |
| chr2:73,926,648–73,927,193 | 252.0 kb | Distal (>10kb) Multiome | 961 | |
| chr2:73,981,145–73,981,910 | 197.3 kb | Distal (>10kb) Multiome | 483 | |
| chr2:73,983,451–73,985,871 | 193.5 kb | Distal (>10kb) Multiome | 821 | |
| chr2:74,002,059–74,003,348 | 176.2 kb | Distal (>10kb) Multiome | 514 | |
| chr2:74,008,705–74,009,321 | 169.9 kb | Distal (>10kb) Multiome | 142 | |
| chr2:74,026,198–74,026,578 | 152.4 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,119,987–74,120,643 | 58.5 kb | Distal (>10kb) Multiome | 969 | |
| chr2:74,147,573–74,148,843 | 30.9 kb | Distal (>10kb) Multiome | 884 | |
| chr2:74,178,147–74,179,324 | 39 bp | At TSS Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 9.4 kb | Proximal (<10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 19.7 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:74,261,293–74,261,813 | 82.8 kb | Distal (>10kb) Multiome | 184 | |
| chr2:74,374,253–74,375,246 | 195.9 kb | Distal (>10kb) Multiome | 158 | |
| chr2:74,379,653–74,380,438 | 201.2 kb | Distal (>10kb) Multiome | 229 | |
| chr2:74,391,129–74,392,484 | 213.1 kb | Distal (>10kb) Multiome | 876 | |
| chr2:74,421,273–74,422,464 | 242.8 kb | Distal (>10kb) Multiome | 756 | |
| chr2:74,426,172–74,426,842 | 247.7 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,440,246–74,442,723 | 263.3 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:74,454,612–74,455,413 | 276.1 kb | Distal (>10kb) Multiome | 982 | |
| chr2:74,457,177–74,459,169 | 279.4 kb | Distal (>10kb) Multiome | 934 | |
| chr2:74,464,912–74,465,776 | 286.5 kb | Distal (>10kb) Multiome | 842 | |
| chr2:74,472,106–74,473,059 | 293.8 kb | Distal (>10kb) Multiome | 1071 |
Genomic view of the MOB1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.