The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for WBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,178,147–74,179,324 | 279.5 kb | Distal (>10kb) Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 270.2 kb | Distal (>10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 259.9 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:74,261,293–74,261,813 | 196.8 kb | Distal (>10kb) Multiome | 184 | |
| chr2:74,374,253–74,375,246 | 83.7 kb | Distal (>10kb) Multiome | 158 | |
| chr2:74,379,653–74,380,438 | 78.4 kb | Distal (>10kb) Multiome | 229 | |
| chr2:74,391,129–74,392,484 | 66.5 kb | Distal (>10kb) Multiome | 876 | |
| chr2:74,421,273–74,422,464 | 36.7 kb | Distal (>10kb) Multiome | 756 | |
| chr2:74,426,172–74,426,842 | 31.8 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,440,246–74,442,723 | 16.3 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:74,454,612–74,455,413 | 3.4 kb | Proximal (<10kb) Multiome | 982 | |
| chr2:74,457,177–74,459,169 | 177 bp | At TSS Multiome | 934 | |
| chr2:74,461,447–74,461,655 | 3.0 kb | Proximal (<10kb) | 172 | |
| chr2:74,464,912–74,465,776 | 6.9 kb | Proximal (<10kb) Multiome | 842 | |
| chr2:74,472,106–74,473,059 | 14.2 kb | Distal (>10kb) Multiome | 1071 | |
| chr2:74,481,955–74,483,673 | 24.7 kb | Distal (>10kb) Multiome | 1031 | |
| chr2:74,497,707–74,500,027 | 41.0 kb | Distal (>10kb) Multiome | 553 | |
| chr2:74,502,724–74,504,160 | 44.8 kb | Distal (>10kb) Multiome | 816 | |
| chr2:74,506,905–74,508,524 | 49.2 kb | Distal (>10kb) Multiome | 1063 | |
| chr2:74,515,477–74,516,725 | 58.0 kb | Distal (>10kb) Multiome | 262 | |
| chr2:74,529,210–74,530,815 | 71.4 kb | Distal (>10kb) Multiome | 988 | |
| chr2:74,548,706–74,549,795 | 91.0 kb | Distal (>10kb) Multiome | 625 | |
| chr2:74,553,035–74,555,636 | 96.1 kb | Distal (>10kb) Multiome | 768 | |
| chr2:74,647,804–74,648,489 | 189.8 kb | Distal (>10kb) Multiome | 232 | |
| chr2:74,653,808–74,654,908 | 195.8 kb | Distal (>10kb) Multiome | 658 | |
| chr2:74,715,073–74,715,890 | 256.9 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the WBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.