DE-10

Supermodule 321 genes

Endosomal transport and cellular import functions

This 327-gene module includes HIF1A, SRC, MCL1, AHR, and RUNX2, with enriched terms related to endosomal transport, import into cell, and endocytosis. Knockdown of RFX7, SOX11, DR1, SETDB1, and SOX4 activates this module. Knockdown of ARID1A, SMARCC1, GATAD2A, MIXL1, and ETV5 represses this module.

Key terms: vesicle-mediated transport transport endosomal transport intracellular transport regulation of cellular process Notable genes: HIF1A SRC MCL1 AHR RUNX2 TIMP2 TGFBR2 XIAP Top TFs: ARID1A SMARCC1 RFX7 SOX11 GATAD2A

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (10)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-10.1	28	AHR TGFBR2 NPC1 GCH1 USP28
DE-10.2	27	RAB1A GFPT1 SEL1L UGDH HYOU1
DE-10.3	24	NF2 CTTN ACTN4 GCLC CAMK2G
DE-10.4	20	CD46 GRB2 RAB5A RAB7A CDK7
DE-10.5	19	RUNX2 XIAP MFSD8 FBH1 ARHGEF18
DE-10.6	18	HIF1A POLR2A STX6 UHMK1 RAB43
DE-10.7	14	MAPK9 SMYD2 AVEN SETD3 AAGAB
DE-10.8	11	LIN28A F11R SKIL PRKD2 RALB
DE-10.9	10	GABPA FIP1L1 SLC12A7 TRIT1 PIGG
DE-10.10	10	PTPN1 RAP1B MAPK6 RAB21 FBXL3

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).