SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
Transcription factors with Perturb-seq knockdown data for SMYD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMYD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMYD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:213,982,546–213,986,860 | 296.6 kb | Distal (>10kb) Multiome | 731 | |
| chr1:213,987,385–213,990,006 | 293.3 kb | Distal (>10kb) Multiome | 745 | |
| chr1:214,122,937–214,123,675 | 157.9 kb | Distal (>10kb) Multiome | 368 | |
| chr1:214,154,263–214,155,345 | 126.5 kb | Distal (>10kb) Multiome | 230 | |
| chr1:214,280,447–214,282,049 | 65 bp | At TSS Multiome | 869 | |
| chr1:214,289,711–214,290,215 | 8.8 kb | Proximal (<10kb) Multiome | 178 | |
| chr1:214,316,395–214,317,010 | 35.6 kb | Distal (>10kb) Multiome HiCAR | 226 | |
| chr1:214,317,130–214,317,628 | 36.3 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr1:214,378,748–214,380,041 | 98.4 kb | Distal (>10kb) Multiome | 127 | |
| chr1:214,446,675–214,447,519 | 165.8 kb | Distal (>10kb) Multiome | 415 | |
| chr1:214,550,016–214,553,159 | 270.6 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the SMYD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.