This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SRC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:37,095,487–37,096,500 | 250.3 kb | Distal (>10kb) Multiome | 1181 | |
| chr20:37,178,598–37,179,693 | 167.0 kb | Distal (>10kb) Multiome | 977 | |
| chr20:37,289,329–37,289,991 | 56.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr20:37,319,185–37,319,833 | 26.6 kb | Distal (>10kb) Multiome | 87 | |
| chr20:37,345,682–37,346,478 | 62 bp | At TSS Multiome | 557 | |
| chr20:37,396,207–37,397,008 | 50.5 kb | Distal (>10kb) Multiome | 227 | |
| chr20:37,406,385–37,406,839 | 10.0 kb | Proximal (<10kb) | 778 | |
| chr20:37,520,318–37,521,734 | 175.2 kb | Distal (>10kb) Multiome | 237 | |
| chr20:37,527,439–37,528,617 | 181.9 kb | Distal (>10kb) Multiome | 899 | |
| chr20:37,564,323–37,564,876 | 218.5 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the SRC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.