The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,726,326–51,726,848 | 292.7 kb | Distal (>10kb) Multiome | 334 | |
| chr15:51,736,980–51,738,047 | 281.7 kb | Distal (>10kb) Multiome | 521 | |
| chr15:51,751,070–51,752,267 | 267.7 kb | Distal (>10kb) Multiome | 433 | |
| chr15:51,829,316–51,830,426 | 189.5 kb | Distal (>10kb) Multiome | 787 | |
| chr15:51,971,175–51,972,397 | 47.4 kb | Distal (>10kb) Multiome | 887 | |
| chr15:52,008,542–52,009,373 | 10.3 kb | Distal (>10kb) Multiome | 499 | |
| chr15:52,011,887–52,012,503 | 6.7 kb | Proximal (<10kb) | 120 | |
| chr15:52,018,740–52,020,253 | 64 bp | At TSS Multiome | 1045 | |
| chr15:52,111,990–52,112,768 | 93.2 kb | Distal (>10kb) Multiome | 189 | |
| chr15:52,139,658–52,140,475 | 120.7 kb | Distal (>10kb) Multiome | 400 | |
| chr15:52,179,295–52,180,708 | 160.5 kb | Distal (>10kb) Multiome | 715 | |
| chr15:52,261,434–52,262,154 | 242.7 kb | Distal (>10kb) Multiome | 313 | |
| chr15:52,294,913–52,296,036 | 276.5 kb | Distal (>10kb) Multiome | 630 |
Genomic view of the MAPK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.