The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for CAMK2G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMK2G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMK2G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,591,236–73,591,781 | 283.1 kb | Distal (>10kb) Multiome | 359 | |
| chr10:73,591,961–73,592,227 | 282.5 kb | Distal (>10kb) Multiome | 458 | |
| chr10:73,625,111–73,626,369 | 248.6 kb | Distal (>10kb) Multiome | 810 | |
| chr10:73,647,157–73,648,042 | 227.0 kb | Distal (>10kb) Multiome | 238 | |
| chr10:73,730,165–73,730,854 | 144.0 kb | Distal (>10kb) Multiome | 823 | |
| chr10:73,741,689–73,742,673 | 132.4 kb | Distal (>10kb) Multiome | 190 | |
| chr10:73,743,801–73,744,894 | 130.2 kb | Distal (>10kb) Multiome | 962 | |
| chr10:73,771,782–73,773,237 | 101.8 kb | Distal (>10kb) Multiome | 918 | |
| chr10:73,781,688–73,782,352 | 92.5 kb | Distal (>10kb) Multiome | 721 | |
| chr10:73,785,180–73,785,869 | 89.1 kb | Distal (>10kb) Multiome | 745 | |
| chr10:73,810,828–73,812,285 | 62.7 kb | Distal (>10kb) Multiome | 876 | |
| chr10:73,817,045–73,817,772 | 57.2 kb | Distal (>10kb) Multiome | 123 | |
| chr10:73,823,062–73,824,101 | 51.0 kb | Distal (>10kb) Multiome | 130 | |
| chr10:73,873,847–73,875,246 | 71 bp | At TSS Multiome | 654 | |
| chr10:73,879,702–73,879,920 | 5.1 kb | Proximal (<10kb) | 519 | |
| chr10:73,906,669–73,907,201 | 32.3 kb | Distal (>10kb) Multiome | 417 | |
| chr10:73,910,388–73,911,812 | 36.5 kb | Distal (>10kb) Multiome | 486 | |
| chr10:73,965,730–73,966,725 | 91.7 kb | Distal (>10kb) Multiome | 552 | |
| chr10:73,994,650–73,995,392 | 120.6 kb | Distal (>10kb) Multiome | 69 | |
| chr10:73,997,294–73,999,626 | 123.4 kb | Distal (>10kb) Multiome | 964 | |
| chr10:74,150,306–74,151,881 | 276.6 kb | Distal (>10kb) Multiome | 926 | |
| chr10:75,209,910–75,211,260 | 1336.0 kb | Distal (>10kb) Multiome HiCAR | 1059 |
Genomic view of the CAMK2G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.