This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CTTN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTTN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTTN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:70,141,113–70,142,538 | 256.8 kb | Distal (>10kb) Multiome | 319 | |
| chr11:70,202,749–70,203,803 | 195.3 kb | Distal (>10kb) Multiome | 782 | |
| chr11:70,213,835–70,214,626 | 184.3 kb | Distal (>10kb) Multiome | 51 | |
| chr11:70,219,601–70,220,630 | 178.4 kb | Distal (>10kb) Multiome | 148 | |
| chr11:70,269,844–70,271,534 | 128.0 kb | Distal (>10kb) Multiome | 790 | |
| chr11:70,397,703–70,399,001 | 83 bp | At TSS Multiome | 843 |
Genomic view of the CTTN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.