The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for USP28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:113,628,900–113,629,434 | 246.4 kb | Distal (>10kb) Multiome | 147 | |
| chr11:113,681,336–113,682,352 | 193.9 kb | Distal (>10kb) Multiome | 213 | |
| chr11:113,773,177–113,774,192 | 101.8 kb | Distal (>10kb) Multiome | 794 | |
| chr11:113,849,620–113,850,143 | 25.6 kb | Distal (>10kb) Multiome | 178 | |
| chr11:113,874,813–113,876,131 | 94 bp | At TSS Multiome | 847 | |
| chr11:113,884,168–113,884,605 | 8.6 kb | Proximal (<10kb) | 114 | |
| chr11:113,974,802–113,975,612 | 99.6 kb | Distal (>10kb) Multiome | 340 | |
| chr11:114,035,962–114,036,615 | 160.8 kb | Distal (>10kb) Multiome | 488 | |
| chr11:114,058,960–114,061,502 | 184.1 kb | Distal (>10kb) Multiome | 421 | |
| chr11:114,077,593–114,078,980 | 202.4 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the USP28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.