This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for RAB1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:64,859,294–64,860,146 | 270.3 kb | Distal (>10kb) Multiome | 654 | |
| chr2:64,864,705–64,865,856 | 264.5 kb | Distal (>10kb) Multiome | 538 | |
| chr2:65,055,719–65,057,013 | 73.8 kb | Distal (>10kb) Multiome | 991 | |
| chr2:65,077,079–65,077,793 | 52.6 kb | Distal (>10kb) Multiome | 133 | |
| chr2:65,129,449–65,131,116 | 249 bp | At TSS Multiome | 977 | |
| chr2:65,133,694–65,133,912 | 3.6 kb | Proximal (<10kb) | 31 | |
| chr2:65,137,434–65,137,879 | 7.3 kb | Proximal (<10kb) | 108 | |
| chr2:65,227,140–65,228,436 | 97.6 kb | Distal (>10kb) Multiome | 971 | |
| chr2:65,331,150–65,331,849 | 201.4 kb | Distal (>10kb) Multiome | 47 | |
| chr2:65,350,820–65,351,607 | 221.2 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the RAB1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.