Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for F11R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = F11R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of F11R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,726,492–160,727,108 | 294.3 kb | Distal (>10kb) Multiome | 322 | |
| chr1:160,910,331–160,911,177 | 110.5 kb | Distal (>10kb) Multiome | 97 | |
| chr1:160,947,055–160,947,669 | 73.7 kb | Distal (>10kb) Multiome | 35 | |
| chr1:160,948,561–160,949,851 | 71.7 kb | Distal (>10kb) Multiome | 173 | |
| chr1:160,981,323–160,982,552 | 39.4 kb | Distal (>10kb) Multiome | 156 | |
| chr1:161,013,713–161,014,009 | 7.1 kb | Proximal (<10kb) | 774 | |
| chr1:161,020,536–161,021,920 | 110 bp | At TSS Multiome | 846 | |
| chr1:161,038,489–161,039,130 | 17.8 kb | Distal (>10kb) Multiome | 468 | |
| chr1:161,045,080–161,046,516 | 24.8 kb | Distal (>10kb) Multiome | 927 | |
| chr1:161,097,691–161,099,047 | 77.1 kb | Distal (>10kb) Multiome | 829 | |
| chr1:161,117,504–161,118,419 | 96.9 kb | Distal (>10kb) Multiome | 794 | |
| chr1:161,131,760–161,133,351 | 111.5 kb | Distal (>10kb) Multiome | 956 | |
| chr1:161,153,700–161,154,461 | 132.9 kb | Distal (>10kb) Multiome | 816 | |
| chr1:161,158,928–161,160,167 | 138.4 kb | Distal (>10kb) Multiome | 706 | |
| chr1:161,165,740–161,167,170 | 145.2 kb | Distal (>10kb) Multiome | 888 | |
| chr1:161,176,874–161,177,972 | 156.4 kb | Distal (>10kb) Multiome | 910 | |
| chr1:161,198,215–161,199,209 | 177.4 kb | Distal (>10kb) Multiome | 357 | |
| chr1:161,201,572–161,202,783 | 181.2 kb | Distal (>10kb) Multiome | 852 | |
| chr1:161,225,326–161,226,910 | 204.8 kb | Distal (>10kb) Multiome | 710 | |
| chr1:161,227,235–161,227,802 | 206.4 kb | Distal (>10kb) Multiome | 372 | |
| chr1:161,258,515–161,259,098 | 237.6 kb | Distal (>10kb) Multiome | 281 | |
| chr1:161,305,737–161,306,708 | 285.1 kb | Distal (>10kb) Multiome | 430 | |
| chr1:161,313,977–161,314,703 | 293.2 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the F11R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.