RAB7A

RAB7A, member RAS oncogene family | CMT2B, RAB7

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

Member of: DE-10 DE-10.4

Biological processes 72 terms

G protein activity (GO:0003925)G protein activity (GO:0003925)GDP binding (GO:0019003)GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)autophagosome assembly (GO:0000045)autophagosome membrane (GO:0000421)bounding membrane of organelle (GO:0098588)cholesterol homeostasis (GO:0042632)cytoplasmic vesicle (GO:0031410)cytosol (GO:0005829)cytosol (GO:0005829)early endosome to late endosome transport (GO:0045022)endocytosis (GO:0006897)endosome membrane (GO:0010008)endosome membrane (GO:0010008)endosome membrane (GO:0010008)endosome membrane (GO:0010008)endosome to lysosome transport (GO:0008333)endosome to lysosome transport (GO:0008333)endosome to plasma membrane protein transport (GO:0099638)epidermal growth factor catabolic process (GO:0007174)extracellular exosome (GO:0070062)late endosome (GO:0005770)late endosome (GO:0005770)late endosome (GO:0005770)late endosome (GO:0005770)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)lipid droplet (GO:0005811)lipid droplet (GO:0005811)lipophagy (GO:0061724)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosome (GO:0005764)lysosome (GO:0005764)lysosome (GO:0005764)lysosome to ER cholesterol transport (GO:0090120)melanosome membrane (GO:0033162)mitochondrial membrane (GO:0031966)mitochondrion (GO:0005739)negative regulation of exosomal secretion (GO:1903542)negative regulation of intralumenal vesicle formation (GO:1905366)phagocytic vesicle (GO:0045335)phagocytic vesicle (GO:0045335)phagocytic vesicle membrane (GO:0030670)phagocytic vesicle membrane (GO:0030670)phagosome acidification (GO:0090383)phagosome maturation (GO:0090382)phagosome-lysosome fusion (GO:0090385)phagosome-lysosome fusion (GO:0090385)plasma membrane (GO:0005886)positive regulation of exosomal secretion (GO:1903543)positive regulation of protein catabolic process (GO:0045732)positive regulation of viral process (GO:0048524)protein binding (GO:0005515)protein localization to lysosome (GO:0061462)protein targeting to lysosome (GO:0006622)protein to membrane docking (GO:0022615)protein transport (GO:0015031)protein-containing complex (GO:0032991)response to bacterium (GO:0009617)retrograde transport, endosome to Golgi (GO:0042147)retromer complex (GO:0030904)retromer complex binding (GO:1905394)secretory granule membrane (GO:0030667)sterol sensor activity (GO:0032935)viral release from host cell (GO:0019076)

Expression (TPM)

TFs regulating RAB7A 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RAB7A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:128,426,214–128,426,887	299.6 kb	Distal (>10kb) Multiome	505
chr3:128,432,305–128,433,430	293.1 kb	Distal (>10kb) Multiome	265
chr3:128,456,900–128,457,416	268.9 kb	Distal (>10kb) Multiome	127
chr3:128,487,682–128,488,679	238.1 kb	Distal (>10kb) Multiome	710
chr3:128,489,907–128,490,591	235.9 kb	Distal (>10kb) Multiome	413
chr3:128,492,255–128,493,190	233.3 kb	Distal (>10kb) Multiome	270
chr3:128,497,309–128,498,144	228.3 kb	Distal (>10kb) Multiome	464
chr3:128,581,519–128,582,200	144.3 kb	Distal (>10kb) Multiome	16
chr3:128,607,947–128,608,800	117.7 kb	Distal (>10kb) Multiome	376
chr3:128,617,357–128,618,496	108.4 kb	Distal (>10kb) Multiome	735
chr3:128,650,142–128,651,178	75.3 kb	Distal (>10kb) Multiome	772
chr3:128,653,061–128,654,283	72.3 kb	Distal (>10kb) Multiome	55
chr3:128,675,353–128,676,166	50.2 kb	Distal (>10kb) Multiome	103
chr3:128,680,397–128,681,422	45.2 kb	Distal (>10kb) Multiome	1014
chr3:128,698,248–128,698,988	27.6 kb	Distal (>10kb) Multiome	239
chr3:128,725,886–128,726,915	39 bp	At TSS Multiome	900
chr3:128,832,889–128,833,369	107.0 kb	Distal (>10kb) Multiome	38
chr3:128,845,614–128,846,390	119.8 kb	Distal (>10kb) Multiome	538
chr3:128,878,828–128,880,293	153.4 kb	Distal (>10kb) Multiome	1016
chr3:128,993,367–128,994,455	267.9 kb	Distal (>10kb) Multiome	344

Genome Browser

Genomic view of the RAB7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.