This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:5,623,013–5,623,598 | 267.0 kb | Distal (>10kb) Multiome | 611 | |
| chr10:5,665,943–5,666,966 | 223.7 kb | Distal (>10kb) Multiome | 720 | |
| chr10:5,684,325–5,685,785 | 205.6 kb | Distal (>10kb) Multiome | 1140 | |
| chr10:5,692,454–5,693,306 | 197.4 kb | Distal (>10kb) Multiome | 757 | |
| chr10:5,697,995–5,698,400 | 192.1 kb | Distal (>10kb) Multiome | 69 | |
| chr10:5,812,699–5,814,342 | 76.7 kb | Distal (>10kb) Multiome | 1126 | |
| chr10:5,866,673–5,867,954 | 22.9 kb | Distal (>10kb) Multiome | 153 | |
| chr10:5,888,755–5,891,014 | 200 bp | At TSS Multiome | 918 | |
| chr10:5,892,799–5,893,078 | 2.6 kb | Proximal (<10kb) | 13 | |
| chr10:5,976,561–5,978,337 | 87.7 kb | Distal (>10kb) Multiome | 723 | |
| chr10:6,086,345–6,087,026 | 196.3 kb | Distal (>10kb) Multiome | 467 | |
| chr10:6,088,532–6,090,276 | 198.7 kb | Distal (>10kb) Multiome | 847 | |
| chr10:6,108,563–6,109,206 | 218.6 kb | Distal (>10kb) Multiome | 207 | |
| chr10:6,144,513–6,146,019 | 254.7 kb | Distal (>10kb) Multiome | 592 | |
| chr10:6,151,133–6,151,901 | 261.3 kb | Distal (>10kb) Multiome | 300 | |
| chr10:6,163,382–6,164,228 | 273.5 kb | Distal (>10kb) Multiome | 706 | |
| chr10:6,184,834–6,185,745 | 295.1 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the FBH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.