This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for XIAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XIAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XIAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:123,648,282–123,649,200 | 211.1 kb | Distal (>10kb) Multiome | 228 | |
| chrX:123,764,958–123,765,499 | 94.7 kb | Distal (>10kb) Multiome | 449 | |
| chrX:123,777,153–123,778,268 | 82.1 kb | Distal (>10kb) Multiome | 304 | |
| chrX:123,819,503–123,820,137 | 40.1 kb | Distal (>10kb) Multiome | 137 | |
| chrX:123,851,009–123,851,295 | 8.5 kb | Proximal (<10kb) | 71 | |
| chrX:123,859,576–123,860,648 | 188 bp | At TSS Multiome | 739 | |
| chrX:123,864,842–123,865,356 | 5.2 kb | Proximal (<10kb) Multiome | 63 | |
| chrX:123,959,874–123,960,635 | 100.5 kb | Distal (>10kb) Multiome | 606 | |
| chrX:123,960,800–123,962,121 | 101.8 kb | Distal (>10kb) Multiome | 588 | |
| chrX:123,962,799–123,963,352 | 103.4 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the XIAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.