This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for MCL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,281,629–150,283,038 | 297.2 kb | Distal (>10kb) Multiome | 503 | |
| chr1:150,293,680–150,294,144 | 285.8 kb | Distal (>10kb) Multiome | 755 | |
| chr1:150,313,761–150,314,506 | 265.5 kb | Distal (>10kb) Multiome | 108 | |
| chr1:150,321,137–150,321,825 | 258.1 kb | Distal (>10kb) Multiome | 806 | |
| chr1:150,363,368–150,364,980 | 215.6 kb | Distal (>10kb) Multiome | 971 | |
| chr1:150,487,154–150,487,710 | 92.3 kb | Distal (>10kb) Multiome | 929 | |
| chr1:150,515,085–150,516,227 | 63.9 kb | Distal (>10kb) Multiome | 781 | |
| chr1:150,548,849–150,549,823 | 30.4 kb | Distal (>10kb) Multiome | 620 | |
| chr1:150,560,828–150,562,623 | 18.3 kb | Distal (>10kb) Multiome | 897 | |
| chr1:150,578,554–150,580,300 | 16 bp | At TSS Multiome | 990 | |
| chr1:150,629,012–150,630,122 | 49.9 kb | Distal (>10kb) Multiome | 875 | |
| chr1:150,634,804–150,635,486 | 55.6 kb | Distal (>10kb) Multiome | 113 | |
| chr1:150,641,008–150,641,820 | 62.0 kb | Distal (>10kb) Multiome | 66 | |
| chr1:150,696,984–150,697,716 | 117.7 kb | Distal (>10kb) Multiome | 619 | |
| chr1:150,875,863–150,877,222 | 297.1 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the MCL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.