This 28-gene module includes AHR, TGFBR2, NPC1, GCH1, and USP28, with enrichment in aryl hydrocarbon receptor signaling, transforming growth factor-beta signaling, and cellular metabolic processes. Knockdown of SMARCC1 represses this module, suggesting that chromatin remodeling activity supports its expression during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.