The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for SEL1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEL1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEL1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:81,323,510–81,324,729 | 209.7 kb | Distal (>10kb) Multiome | 380 | |
| chr14:81,385,875–81,386,791 | 147.4 kb | Distal (>10kb) Multiome | 212 | |
| chr14:81,435,308–81,437,022 | 97.3 kb | Distal (>10kb) Multiome | 802 | |
| chr14:81,522,513–81,524,320 | 10.2 kb | Distal (>10kb) Multiome | 184 | |
| chr14:81,533,402–81,534,447 | 128 bp | At TSS Multiome | 697 | |
| chr14:81,561,083–81,562,335 | 27.7 kb | Distal (>10kb) Multiome | 190 | |
| chr14:81,613,059–81,614,231 | 79.8 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the SEL1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.