This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for RAB21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:71,460,389–71,462,756 | 293.9 kb | Distal (>10kb) Multiome | 231 | |
| chr12:71,662,923–71,664,744 | 90.8 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:71,671,386–71,672,338 | 82.9 kb | Distal (>10kb) Multiome | 185 | |
| chr12:71,685,622–71,686,597 | 68.6 kb | Distal (>10kb) Multiome | 910 | |
| chr12:71,747,074–71,747,504 | 7.4 kb | Proximal (<10kb) | 205 | |
| chr12:71,752,978–71,753,144 | 1.7 kb | Proximal (<10kb) | 157 | |
| chr12:71,754,180–71,755,575 | 9 bp | At TSS Multiome | 892 | |
| chr12:71,839,299–71,840,331 | 84.9 kb | Distal (>10kb) Multiome | 972 | |
| chr12:71,938,597–71,939,301 | 184.1 kb | Distal (>10kb) Multiome | 651 | |
| chr12:71,947,591–71,948,143 | 193.1 kb | Distal (>10kb) Multiome | 370 |
Genomic view of the RAB21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.