This gene encodes an enzyme involved in glycosylphosphatidylinositol-anchor biosynthesis. The encoded protein, which is localized to the endoplasmic reticulum, is involved in transferring ethanoloamine phosphate to mannose 2 of glycosylphosphatidylinositol species H7 to form species H8. Allelic variants of this gene have been associated with intellectual disability, hypotonia, and early-onset seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for PIGG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:212,417–212,910 | 286.5 kb | Distal (>10kb) Multiome | 155 | |
| chr4:304,967–305,746 | 193.7 kb | Distal (>10kb) Multiome | 151 | |
| chr4:336,352–338,341 | 161.5 kb | Distal (>10kb) Multiome | 493 | |
| chr4:473,613–474,432 | 25.0 kb | Distal (>10kb) Multiome | 745 | |
| chr4:498,731–499,543 | 23 bp | At TSS Multiome | 869 | |
| chr4:575,294–576,132 | 76.2 kb | Distal (>10kb) Multiome | 154 | |
| chr4:663,207–664,324 | 164.6 kb | Distal (>10kb) Multiome | 298 | |
| chr4:673,501–675,336 | 175.2 kb | Distal (>10kb) Multiome | 920 | |
| chr4:680,919–681,550 | 182.2 kb | Distal (>10kb) Multiome | 275 | |
| chr4:688,280–689,636 | 190.1 kb | Distal (>10kb) Multiome | 218 | |
| chr4:705,313–706,398 | 206.5 kb | Distal (>10kb) Multiome | 613 | |
| chr4:781,187–782,732 | 282.8 kb | Distal (>10kb) Multiome | 893 |
Genomic view of the PIGG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.