This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]
Transcription factors with Perturb-seq knockdown data for NF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,304,664–29,307,808 | 296.6 kb | Distal (>10kb) Multiome | 839 | |
| chr22:29,313,065–29,313,784 | 290.2 kb | Distal (>10kb) Multiome | 274 | |
| chr22:29,315,074–29,316,064 | 288.0 kb | Distal (>10kb) Multiome | 242 | |
| chr22:29,388,161–29,388,971 | 215.0 kb | Distal (>10kb) Multiome | 740 | |
| chr22:29,431,916–29,432,715 | 171.3 kb | Distal (>10kb) Multiome | 14 | |
| chr22:29,470,132–29,470,844 | 133.1 kb | Distal (>10kb) Multiome | 437 | |
| chr22:29,480,003–29,481,437 | 122.5 kb | Distal (>10kb) Multiome | 384 | |
| chr22:29,553,345–29,553,988 | 49.8 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,580,084–29,581,520 | 22.5 kb | Distal (>10kb) Multiome | 856 | |
| chr22:29,603,006–29,604,162 | 80 bp | At TSS Multiome | 803 | |
| chr22:29,766,399–29,767,654 | 163.5 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,837,985–29,838,559 | 234.8 kb | Distal (>10kb) Multiome | 690 | |
| chr22:29,882,926–29,883,914 | 279.6 kb | Distal (>10kb) Multiome | 628 |
Genomic view of the NF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.