The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for UGDH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UGDH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UGDH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:39,365,894–39,366,933 | 161.3 kb | Distal (>10kb) Multiome | 1045 | |
| chr4:39,446,525–39,447,613 | 80.5 kb | Distal (>10kb) Multiome | 443 | |
| chr4:39,458,264–39,459,604 | 68.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr4:39,526,691–39,528,369 | 33 bp | At TSS Multiome | 1061 | |
| chr4:39,558,019–39,558,995 | 30.8 kb | Distal (>10kb) Multiome | 500 | |
| chr4:39,635,065–39,635,553 | 107.7 kb | Distal (>10kb) Multiome | 157 | |
| chr4:39,637,938–39,639,954 | 111.4 kb | Distal (>10kb) Multiome HiCAR | 976 | |
| chr4:39,697,357–39,698,855 | 170.5 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the UGDH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.