This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:76,884,124–76,887,820 | 140.7 kb | Distal (>10kb) Multiome | 744 | |
| chr13:76,979,798–76,980,501 | 46.9 kb | Distal (>10kb) Multiome | 498 | |
| chr13:76,991,141–76,993,015 | 35.0 kb | Distal (>10kb) Multiome | 951 | |
| chr13:77,025,218–77,025,707 | 1.5 kb | Proximal (<10kb) | 85 | |
| chr13:77,026,148–77,027,636 | 39 bp | At TSS Multiome | 762 | |
| chr13:77,047,482–77,049,282 | 20.9 kb | Distal (>10kb) Multiome | 304 | |
| chr13:77,325,949–77,327,619 | 300.0 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the FBXL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.