The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PRKD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:46,413,092–46,414,029 | 283.7 kb | Distal (>10kb) Multiome | 530 | |
| chr19:46,416,168–46,416,925 | 280.8 kb | Distal (>10kb) Multiome | 522 | |
| chr19:46,426,339–46,427,101 | 270.6 kb | Distal (>10kb) Multiome | 220 | |
| chr19:46,471,149–46,471,898 | 225.8 kb | Distal (>10kb) Multiome | 339 | |
| chr19:46,495,489–46,496,206 | 201.4 kb | Distal (>10kb) Multiome | 177 | |
| chr19:46,587,845–46,588,467 | 109.2 kb | Distal (>10kb) Multiome | 21 | |
| chr19:46,600,411–46,601,577 | 96.3 kb | Distal (>10kb) Multiome | 1006 | |
| chr19:46,633,826–46,635,061 | 63.0 kb | Distal (>10kb) Multiome | 365 | |
| chr19:46,638,437–46,639,929 | 58.3 kb | Distal (>10kb) Multiome | 741 | |
| chr19:46,659,987–46,662,280 | 36.0 kb | Distal (>10kb) Multiome | 691 | |
| chr19:46,696,102–46,696,440 | 900 bp | At TSS | 17 | |
| chr19:46,696,773–46,698,048 | 176 bp | At TSS Multiome | 408 | |
| chr19:46,704,563–46,704,746 | 7.2 kb | Proximal (<10kb) | 257 | |
| chr19:46,710,667–46,710,982 | 3.3 kb | Proximal (<10kb) | 56 | |
| chr19:46,713,710–46,714,718 | 16.8 kb | Distal (>10kb) Multiome | 566 | |
| chr19:46,716,011–46,716,589 | 1.7 kb | Proximal (<10kb) | 236 | |
| chr19:46,716,676–46,717,696 | 19.8 kb | Distal (>10kb) Multiome | 487 | |
| chr19:46,745,601–46,746,962 | 49.1 kb | Distal (>10kb) Multiome | 561 | |
| chr19:46,787,215–46,789,013 | 91.3 kb | Distal (>10kb) Multiome | 944 | |
| chr19:46,850,211–46,851,336 | 153.5 kb | Distal (>10kb) Multiome | 946 | |
| chr19:46,855,920–46,856,711 | 158.9 kb | Distal (>10kb) Multiome | 610 | |
| chr19:46,859,815–46,861,611 | 163.0 kb | Distal (>10kb) Multiome | 1061 |
Genomic view of the PRKD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.