Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018]
Transcription factors with Perturb-seq knockdown data for ARHGEF18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,098,739–7,099,728 | 295.9 kb | Distal (>10kb) Multiome HiCAR | 683 | |
| chr19:7,197,125–7,197,557 | 197.9 kb | Distal (>10kb) Multiome | 652 | |
| chr19:7,197,811–7,198,607 | 196.9 kb | Distal (>10kb) Multiome | 815 | |
| chr19:7,293,755–7,294,636 | 100.7 kb | Distal (>10kb) Multiome | 668 | |
| chr19:7,394,774–7,395,629 | 77 bp | At TSS Multiome | 601 | |
| chr19:7,482,657–7,483,489 | 88.0 kb | Distal (>10kb) Multiome | 201 | |
| chr19:7,488,712–7,489,463 | 93.9 kb | Distal (>10kb) Multiome | 542 | |
| chr19:7,500,843–7,501,401 | 106.0 kb | Distal (>10kb) Multiome | 556 | |
| chr19:7,505,850–7,507,270 | 111.4 kb | Distal (>10kb) Multiome | 516 | |
| chr19:7,507,812–7,508,356 | 112.9 kb | Distal (>10kb) Multiome | 168 | |
| chr19:7,522,263–7,523,208 | 127.4 kb | Distal (>10kb) Multiome | 917 | |
| chr19:7,533,976–7,536,472 | 138.9 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 156.2 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 160.1 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 200.6 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 234.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 241.9 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 285.6 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the ARHGEF18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.