The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:69,093,377–69,094,772 | 140.9 kb | Distal (>10kb) Multiome | 952 | |
| chr5:69,166,575–69,167,819 | 67.8 kb | Distal (>10kb) Multiome | 840 | |
| chr5:69,188,979–69,190,115 | 45.3 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,217,542–69,218,587 | 16.9 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,233,011–69,233,762 | 1.1 kb | Proximal (<10kb) | 8 | |
| chr5:69,233,877–69,234,185 | 692 bp | At TSS | 15 | |
| chr5:69,234,302–69,235,305 | 50 bp | At TSS Multiome | 732 | |
| chr5:69,300,544–69,301,286 | 66.0 kb | Distal (>10kb) Multiome | 217 | |
| chr5:69,368,998–69,370,235 | 134.8 kb | Distal (>10kb) Multiome | 956 | |
| chr5:69,414,852–69,415,897 | 180.3 kb | Distal (>10kb) Multiome | 714 | |
| chr5:69,492,169–69,494,057 | 257.8 kb | Distal (>10kb) Multiome | 821 | |
| chr5:69,499,604–69,500,518 | 265.2 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the CDK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.