This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for RAP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:68,331,875–68,332,795 | 278.4 kb | Distal (>10kb) Multiome HiCAR | 616 | |
| chr12:68,365,008–68,365,679 | 245.5 kb | Distal (>10kb) Multiome | 731 | |
| chr12:68,538,810–68,539,554 | 71.7 kb | Distal (>10kb) Multiome | 347 | |
| chr12:68,610,127–68,611,767 | 36 bp | At TSS Multiome | 846 | |
| chr12:68,686,562–68,687,457 | 76.1 kb | Distal (>10kb) Multiome | 987 | |
| chr12:68,745,790–68,746,910 | 135.3 kb | Distal (>10kb) Multiome | 899 | |
| chr12:68,804,279–68,805,301 | 194.0 kb | Distal (>10kb) Multiome | 497 | |
| chr12:68,807,325–68,809,299 | 198.0 kb | Distal (>10kb) Multiome | 1178 |
Genomic view of the RAP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.