Enables protein kinase binding activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC12A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:784,104–785,298 | 327.3 kb | Distal (>10kb) Multiome HiCAR | 316 | |
| chr5:892,342–893,335 | 219.3 kb | Distal (>10kb) Multiome | 802 | |
| chr5:1,004,572–1,005,613 | 107.1 kb | Distal (>10kb) Multiome | 404 | |
| chr5:1,008,462–1,009,631 | 103.3 kb | Distal (>10kb) Multiome | 276 | |
| chr5:1,102,030–1,102,780 | 9.7 kb | Proximal (<10kb) Multiome | 207 | |
| chr5:1,111,233–1,112,367 | 57 bp | At TSS Multiome | 516 | |
| chr5:1,294,274–1,295,675 | 183.1 kb | Distal (>10kb) Multiome | 415 | |
| chr5:1,344,394–1,345,745 | 233.0 kb | Distal (>10kb) Multiome | 652 | |
| chr5:1,385,584–1,386,611 | 273.9 kb | Distal (>10kb) Multiome | 420 |
Genomic view of the SLC12A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.