This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TIMP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,723,107–78,723,697 | 201.9 kb | Distal (>10kb) Multiome | 236 | |
| chr17:78,781,367–78,783,044 | 142.9 kb | Distal (>10kb) Multiome | 847 | |
| chr17:78,839,825–78,841,566 | 84.4 kb | Distal (>10kb) Multiome | 1124 | |
| chr17:78,923,680–78,924,659 | 727 bp | At TSS | 295 | |
| chr17:78,924,768–78,925,859 | 54 bp | At TSS Multiome | 498 | |
| chr17:78,971,335–78,971,892 | 46.2 kb | Distal (>10kb) Multiome | 359 | |
| chr17:79,009,356–79,010,250 | 84.4 kb | Distal (>10kb) Multiome | 703 | |
| chr17:79,023,888–79,024,662 | 99.0 kb | Distal (>10kb) Multiome | 348 | |
| chr17:79,074,462–79,075,529 | 149.4 kb | Distal (>10kb) Multiome | 657 | |
| chr17:79,182,908–79,183,922 | 258.2 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the TIMP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.