This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RALB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,996,816–119,997,661 | 255.6 kb | Distal (>10kb) Multiome | 20 | |
| chr2:120,012,388–120,013,831 | 239.8 kb | Distal (>10kb) Multiome | 973 | |
| chr2:120,222,919–120,223,954 | 29.4 kb | Distal (>10kb) Multiome | 806 | |
| chr2:120,237,598–120,238,948 | 14.6 kb | Distal (>10kb) Multiome | 425 | |
| chr2:120,252,124–120,253,825 | 10 bp | At TSS Multiome | 912 | |
| chr2:120,256,188–120,256,633 | 3.4 kb | Proximal (<10kb) | 26 | |
| chr2:120,343,217–120,343,961 | 90.7 kb | Distal (>10kb) Multiome | 453 | |
| chr2:120,441,791–120,443,631 | 190.4 kb | Distal (>10kb) Multiome | 511 | |
| chr2:120,465,595–120,466,904 | 213.5 kb | Distal (>10kb) Multiome | 829 | |
| chr2:120,552,937–120,553,500 | 300.3 kb | Distal (>10kb) Multiome | 583 |
Genomic view of the RALB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.