Enables syntaxin binding activity. Involved in regulation of protein localization; retrograde transport, endosome to Golgi; and vesicle fusion. Acts upstream of or within endocytic recycling. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of SNARE complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STX6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:180,854,229–180,855,048 | 168.2 kb | Distal (>10kb) Multiome | 299 | |
| chr1:180,911,688–180,913,578 | 109.9 kb | Distal (>10kb) Multiome | 364 | |
| chr1:180,922,741–180,923,870 | 99.5 kb | Distal (>10kb) Multiome | 265 | |
| chr1:180,953,870–180,954,644 | 68.5 kb | Distal (>10kb) Multiome | 386 | |
| chr1:181,021,780–181,023,678 | 162 bp | At TSS Multiome | 965 | |
| chr1:181,035,921–181,036,673 | 13.4 kb | Distal (>10kb) Multiome | 125 | |
| chr1:181,088,088–181,090,529 | 65.8 kb | Distal (>10kb) Multiome | 1072 | |
| chr1:181,099,787–181,100,830 | 77.5 kb | Distal (>10kb) Multiome | 413 | |
| chr1:181,101,491–181,102,447 | 79.2 kb | Distal (>10kb) Multiome | 425 | |
| chr1:181,104,541–181,106,069 | 82.5 kb | Distal (>10kb) Multiome | 849 | |
| chr1:181,142,277–181,142,792 | 119.8 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr1:181,152,896–181,153,600 | 130.2 kb | Distal (>10kb) Multiome | 502 | |
| chr1:181,166,371–181,166,866 | 143.8 kb | Distal (>10kb) Multiome | 327 | |
| chr1:181,179,406–181,181,016 | 157.5 kb | Distal (>10kb) Multiome | 389 | |
| chr1:181,189,592–181,190,403 | 167.2 kb | Distal (>10kb) Multiome | 413 | |
| chr1:181,216,477–181,217,204 | 194.0 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the STX6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.