RAB43
RAB43, member RAS oncogene family | ISY1, RAB11B, RAB41

Enables GTPase activity. Involved in Golgi organization; phagosome maturation; and retrograde transport, plasma membrane to Golgi. Located in Golgi apparatus and phagocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-10 DE-10.6 Developmental clusters: GC6
Biological processes 29 terms
G protein activity (GO:0003925)G protein activity (GO:0003925)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi organization (GO:0007030)autophagosome assembly (GO:0000045)cis-Golgi network membrane (GO:0033106)endomembrane system (GO:0012505)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)extracellular exosome (GO:0070062)intracellular protein transport (GO:0006886)phagocytic vesicle (GO:0045335)phagocytic vesicle (GO:0045335)phagocytic vesicle membrane (GO:0030670)phagosome maturation (GO:0090382)protein binding (GO:0005515)regulation of Golgi organization (GO:1903358)retrograde transport, plasma membrane to Golgi (GO:0035526)trans-Golgi network membrane (GO:0032588)virion assembly (GO:0019068)
Expression (TPM)
RAB43 — as a Regulated Gene

TFs regulating RAB43 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RAB43

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:128,832,889–128,833,369 289.0 kb Distal (>10kb) Multiome 38
chr3:128,845,614–128,846,390 276.2 kb Distal (>10kb) Multiome 538
chr3:128,878,828–128,880,293 242.6 kb Distal (>10kb) Multiome 1016
chr3:128,993,367–128,994,455 128.1 kb Distal (>10kb) Multiome 344
chr3:129,027,026–129,027,525 94.9 kb Distal (>10kb) Multiome 589
chr3:129,045,697–129,046,752 75.6 kb Distal (>10kb) Multiome 170
chr3:129,119,707–129,119,892 2.1 kb Proximal (<10kb) 475
chr3:129,120,244–129,122,947 108 bp At TSS Multiome 767
chr3:129,160,815–129,162,244 39.2 kb Distal (>10kb) Multiome 917
chr3:129,183,284–129,184,525 61.8 kb Distal (>10kb) Multiome 966
chr3:129,249,227–129,250,064 127.4 kb Distal (>10kb) Multiome 767
chr3:129,278,315–129,279,976 156.7 kb Distal (>10kb) Multiome 767
chr3:129,305,525–129,306,095 183.7 kb Distal (>10kb) Multiome 342
chr3:129,314,154–129,316,995 192.8 kb Distal (>10kb) Multiome 949
chr3:129,343,720–129,344,497 221.9 kb Distal (>10kb) Multiome 346
chr3:129,344,512–129,344,822 222.5 kb Distal (>10kb) Multiome 58
chr3:129,359,825–129,360,642 238.3 kb Distal (>10kb) Multiome 65
chr3:129,399,193–129,399,868 277.5 kb Distal (>10kb) Multiome 625

Genome Browser

Genomic view of the RAB43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:128,822,889 – 129,409,868
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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