This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for TRIT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:39,609,639–39,610,339 | 273.6 kb | Distal (>10kb) Multiome | 387 | |
| chr1:39,632,749–39,633,322 | 250.5 kb | Distal (>10kb) Multiome | 174 | |
| chr1:39,639,353–39,640,336 | 243.7 kb | Distal (>10kb) Multiome | 503 | |
| chr1:39,691,164–39,691,639 | 192.1 kb | Distal (>10kb) Multiome | 333 | |
| chr1:39,701,474–39,702,144 | 181.6 kb | Distal (>10kb) Multiome | 352 | |
| chr1:39,738,639–39,739,177 | 144.6 kb | Distal (>10kb) Multiome | 534 | |
| chr1:39,788,434–39,789,609 | 94.5 kb | Distal (>10kb) Multiome | 548 | |
| chr1:39,883,104–39,883,825 | 11 bp | At TSS Multiome | 732 | |
| chr1:39,892,714–39,892,944 | 9.2 kb | Proximal (<10kb) | 346 | |
| chr1:39,893,050–39,893,477 | 9.5 kb | Proximal (<10kb) | 264 | |
| chr1:39,898,602–39,899,404 | 15.6 kb | Distal (>10kb) Multiome | 394 | |
| chr1:39,900,435–39,902,736 | 17.2 kb | Distal (>10kb) Multiome | 848 | |
| chr1:39,922,214–39,922,725 | 39.0 kb | Distal (>10kb) Multiome | 180 | |
| chr1:39,954,782–39,955,493 | 71.6 kb | Distal (>10kb) Multiome | 479 | |
| chr1:40,039,712–40,041,155 | 157.1 kb | Distal (>10kb) Multiome | 992 | |
| chr1:40,096,788–40,097,757 | 213.8 kb | Distal (>10kb) Multiome | 852 | |
| chr1:40,161,107–40,161,976 | 277.8 kb | Distal (>10kb) Multiome | 954 |
Genomic view of the TRIT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.