SETD3
SET domain containing 3, actin N3(tau)-histidine methyltransferase | FLJ23027, C14orf154

Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-10 DE-10.7
Biological processes 23 terms
RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)actin filament organization (GO:0007015)actin filament organization (GO:0007015)chromatin (GO:0000785)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)cytoplasm (GO:0005737)histone H3K36 methyltransferase activity (GO:0046975)histone H3K4 methyltransferase activity (GO:0042800)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein-L-histidine N-tele-methyltransferase activity (GO:0018064)protein-L-histidine N-tele-methyltransferase activity (GO:0018064)protein-L-histidine N-tele-methyltransferase activity (GO:0018064)protein-lysine N-methyltransferase activity (GO:0016279)regulation of uterine smooth muscle contraction (GO:0070472)regulation of uterine smooth muscle contraction (GO:0070472)regulation of uterine smooth muscle contraction (GO:0070472)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)
Expression (TPM)
SETD3 — as a Regulated Gene

TFs regulating SETD3 0 TFs

Transcription factors with Perturb-seq knockdown data for SETD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SETD3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:99,230,631–99,232,582 248.8 kb Distal (>10kb) Multiome 274
chr14:99,245,498–99,247,127 234.9 kb Distal (>10kb) Multiome 314
chr14:99,262,920–99,263,579 217.8 kb Distal (>10kb) Multiome 160
chr14:99,270,416–99,271,381 210.1 kb Distal (>10kb) Multiome 301
chr14:99,271,901–99,274,036 207.5 kb Distal (>10kb) Multiome 584
chr14:99,274,138–99,275,258 206.1 kb Distal (>10kb) Multiome 708
chr14:99,479,847–99,482,007 289 bp At TSS Multiome 803
chr14:99,580,183–99,580,635 99.5 kb Distal (>10kb) Multiome 170
chr14:99,602,979–99,605,771 123.6 kb Distal (>10kb) Multiome 993
chr14:99,663,812–99,664,749 183.4 kb Distal (>10kb) Multiome 215
chr14:99,682,774–99,684,994 201.9 kb Distal (>10kb) Multiome 763
chr14:99,729,847–99,731,033 249.4 kb Distal (>10kb) Multiome 551

Genome Browser

Genomic view of the SETD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:99,220,631 – 99,741,033
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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