Involved in negative regulation of apoptotic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AVEN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AVEN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AVEN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:33,920,935–33,921,652 | 118.0 kb | Distal (>10kb) Multiome | 112 | |
| chr15:34,038,314–34,039,346 | 459 bp | At TSS Multiome | 694 | |
| chr15:34,047,473–34,047,732 | 8.3 kb | Proximal (<10kb) | 306 | |
| chr15:34,101,337–34,102,390 | 62.8 kb | Distal (>10kb) Multiome | 810 | |
| chr15:34,209,514–34,210,513 | 170.7 kb | Distal (>10kb) Multiome | 775 | |
| chr15:34,224,706–34,225,419 | 185.8 kb | Distal (>10kb) Multiome | 856 | |
| chr15:34,337,012–34,338,557 | 298.8 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the AVEN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.