This 20-gene module includes CD46, GRB2, RAB5A, and RAB7A, with enrichment in autophagy-related biological processes including macroautophagy and processes utilizing autophagic mechanisms. Knockdown of MARS, SETDB1, E2F6, and SOX11 activates this module. Knockdown of ARID1A represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.