This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for GFPT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GFPT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GFPT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:69,178,030–69,178,850 | 208.8 kb | Distal (>10kb) Multiome | 832 | |
| chr2:69,306,399–69,307,697 | 79.9 kb | Distal (>10kb) Multiome | 707 | |
| chr2:69,348,684–69,349,416 | 38.2 kb | Distal (>10kb) Multiome | 41 | |
| chr2:69,386,703–69,387,800 | 7 bp | At TSS Multiome | 995 | |
| chr2:69,436,764–69,438,011 | 50.2 kb | Distal (>10kb) Multiome | 972 | |
| chr2:69,450,768–69,451,516 | 63.9 kb | Distal (>10kb) Multiome | 69 | |
| chr2:69,642,875–69,644,362 | 256.6 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the GFPT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.