The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for UHMK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UHMK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UHMK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:162,391,686–162,392,380 | 105.8 kb | Distal (>10kb) Multiome | 276 | |
| chr1:162,443,805–162,444,309 | 53.8 kb | Distal (>10kb) Multiome | 88 | |
| chr1:162,464,538–162,465,124 | 33.0 kb | Distal (>10kb) Multiome | 39 | |
| chr1:162,497,482–162,498,431 | 70 bp | At TSS Multiome | 778 | |
| chr1:162,560,729–162,562,552 | 63.7 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:162,696,268–162,696,983 | 198.8 kb | Distal (>10kb) Multiome | 473 |
Genomic view of the UHMK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.