The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for PTPN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:50,321,165–50,321,654 | 188.9 kb | Distal (>10kb) Multiome | 683 | |
| chr20:50,509,813–50,510,874 | 150 bp | At TSS Multiome | 1005 | |
| chr20:50,635,765–50,636,791 | 125.7 kb | Distal (>10kb) Multiome | 720 | |
| chr20:50,641,661–50,642,825 | 132.1 kb | Distal (>10kb) Multiome | 190 | |
| chr20:50,645,216–50,645,868 | 135.3 kb | Distal (>10kb) Multiome | 792 | |
| chr20:50,730,245–50,732,382 | 220.9 kb | Distal (>10kb) Multiome | 1014 | |
| chr20:50,767,314–50,767,756 | 257.1 kb | Distal (>10kb) Multiome | 140 | |
| chr20:50,790,529–50,791,153 | 280.5 kb | Distal (>10kb) Multiome | 980 | |
| chr20:50,794,408–50,795,648 | 284.6 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the PTPN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.