This module contains 10 genes including PTPN1, RAP1B, MAPK6, RAB21, and FBXL3, with enrichment in protein phosphorylation, small GTPase signaling, and membrane trafficking pathways. Knockdown of SOX17, EOMESODERMIN, and FOXA2 activates this module. Knockdown of NANOG, POU5F1, and OCT4 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.