chr14:20,705,982–20,707,066

chr14 : 20,705,982 – 20,707,066

1,084 bp 110 TFs 10 linked genes

This 1.1 kb open chromatin element is linked to 10 target genes and is bound by 110 transcription factors.

Linked Genes

10 genes

Gene	Expression	Dist. to TSS	Distance	Link type
EGILA		53 bp	At TSS	Proximity
ANG		21.8 kb	Distal	Multiome
RNASE4		21.8 kb	Distal	Multiome
RNASE1		96.5 kb	Distal	Multiome+HiCAR
PNP		237.0 kb	Distal	Multiome
PIP4P1		245.0 kb	Distal	Multiome
APEX1		251.2 kb	Distal	Multiome
OSGEP		251.3 kb	Distal	Multiome
METTL17		283.6 kb	Distal	Multiome
TEP1		293.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

110 transcription factors

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 338 bp overlap

ATF2 2 datasets

ChIP H1 ENCFF295GZO 460 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 168 bp overlap

Motif DE_72h DE_72h-Alx1_MA0854.2 8 bp overlap

Motif DE_72h DE_72h-Alx4_MA0853.2 12 bp overlap

Motif DE_72h DE_72h-Arx_MA0874.2 10 bp overlap

BARX1 1 dataset

Motif DE_72h DE_72h-BARX1_MA0875.2 6 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD3.MV4-11_IBET151_50nM 139 bp overlap

BRD4 3 datasets

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 357 bp overlap

ChIP HCC1395 GSE63581.BRD4.HCC1395 216 bp overlap

ChIP PC-3_GDC-R GSE137207.BRD4.PC-3_GDC-R 191 bp overlap

Motif DE_72h DE_72h-BSX_MA0876.2 6 bp overlap

Bcl11B 1 dataset

Motif DE_72h DE_72h-Bcl11B_MA1989.2 9 bp overlap

CREB1 1 dataset

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 103 bp overlap

CREBBP 1 dataset

ChIP PC-3_GDC-resist GSE147455.CREBBP.PC-3_GDC-resist 242 bp overlap

Motif DE_72h DE_72h-CUX2_MA0755.2 9 bp overlap

Motif DE_72h DE_72h-DLX1_MA0879.3 6 bp overlap

Motif DE_72h DE_72h-DLX6_MA0882.2 6 bp overlap

DMRTA2 3 datasets

Motif DE_48h DE_48h-DMRTA2_MA1478.2 6 bp overlap

Motif DE_60h DE_60h-DMRTA2_MA1478.2 6 bp overlap

Motif DE_72h DE_72h-DMRTA2_MA1478.2 6 bp overlap

Motif DE_72h DE_72h-Dlx3_MA0880.2 6 bp overlap

Motif DE_72h DE_72h-Dlx4_MA0881.2 6 bp overlap

ELF3 2 datasets

ChIP PDAC GSE64557.ELF3.PDAC 127 bp overlap

ChIP PDAC_KOKLF5 GSE64557.ELF3.PDAC_KOKLF5 345 bp overlap

EP300 3 datasets

ChIP H1 ENCFF927IYK 133 bp overlap

ChIP PC-3 GSE147455.EP300.PC-3 159 bp overlap

ChIP WA01 ENCSR000BKK.EP300.WA01 178 bp overlap

ChIP HUVEC-C GSE128382.ERG.HUVEC-C 225 bp overlap

ChIP aortic-endothelial-cell_D13 GSE139377.ERG.aortic-endothelial-cell_D13 172 bp overlap

ChIP aortic-endothelial-cell_D16 GSE139377.ERG.aortic-endothelial-cell_D16 114 bp overlap

ETV5::DRGX 1 dataset

Motif DE_72h DE_72h-ETV5DRGX_MA1944.2 12 bp overlap

Esrrg 2 datasets

Motif DE_60h DE_60h-Esrrg_MA0643.2 9 bp overlap

Motif DE_72h DE_72h-Esrrg_MA0643.2 9 bp overlap

FOXA1 2 datasets

ChIP MCF-7_TNF GSE59530.FOXA1.MCF-7_TNF 185 bp overlap

ChIP NCI-H3122 GSE39998.FOXA1.NCI-H3122 164 bp overlap

FOXA2 1 dataset

ChIP CFPAC-1_HOXB8-OE GSE119930.FOXA2.CFPAC-1_HOXB8-OE 263 bp overlap

GATA2 5 datasets

ChIP HUVEC-C_VEGF_4h GSE109625.GATA2.HUVEC-C_VEGF_4h 71 bp overlap

ChIP SKH1 GSE87283.GATA2.SKH1 136 bp overlap

ChIP endothelial cell of umbilical vein ENCFF148NLK 113 bp overlap

ChIP endothelial_umbilical-vein ENCSR000EVW.GATA2.endothelial_umbilical-vein 181 bp overlap

ChIP primary-endometrial-stromal-cell_IVD_P2 GSE145673.GATA2.primary-endometrial-stromal-cell_IVD_P2 125 bp overlap

GATA6 7 datasets

ChIP DE_D1 S09-DE-d1-GATA6-exp1 208 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 283 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 223 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 492 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 235 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 499 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 370 bp overlap

Motif DE_72h DE_72h-GBX2_MA0890.2 6 bp overlap

HDAC2 2 datasets

ChIP PC-3 GSE147455.HDAC2.PC-3 248 bp overlap

ChIP PC-3 GSE147455.HDAC2.PC-3 74 bp overlap

HESX1 1 dataset

Motif DE_72h DE_72h-HESX1_MA0894.2 6 bp overlap

HOXA7 1 dataset

Motif DE_72h DE_72h-HOXA7_MA1498.3 6 bp overlap

HOXB13 1 dataset

ChIP prostate_2078_T GSE130408.HOXB13.prostate_2078_T 139 bp overlap

Motif DE_72h DE_72h-Hmx1_MA0896.2 9 bp overlap

Motif DE_72h DE_72h-Hmx3_MA0898.2 9 bp overlap

INSM1 3 datasets

Motif DE_48h DE_48h-INSM1_MA0155.1 12 bp overlap

Motif DE_60h DE_60h-INSM1_MA0155.1 12 bp overlap

Motif DE_72h DE_72h-INSM1_MA0155.1 12 bp overlap

JUN 15 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 477 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 337 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 264 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 220 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 602 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 412 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 1084 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 392 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 354 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 422 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 607 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 400 bp overlap

ChIP H1 ENCFF621PNP 178 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 426 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 374 bp overlap

ChIP WA09_heat-shock GSE105028.KLF4.WA09_heat-shock 132 bp overlap

Motif DE_72h DE_72h-LBX2_MA0699.2 6 bp overlap

Motif DE_72h DE_72h-LHX2_MA0700.3 6 bp overlap

MEIS1 2 datasets

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MSX1_MA0666.3 6 bp overlap

Motif DE_72h DE_72h-MSX2_MA0708.3 6 bp overlap

Motif DE_72h DE_72h-Msx3_MA0709.2 6 bp overlap

NANOG 11 datasets

ChIP GM23338 ENCFF065NZG 147 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 97 bp overlap

ChIP H1 ENCFF747ZPQ 209 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 680 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 384 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 294 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 405 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 280 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 280 bp overlap

ChIP hESC GSE20650.NANOG.hESC 127 bp overlap

ChIP hESC GSE18292.NANOG.hESC 66 bp overlap

NFATC3 1 dataset

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

NFATC4 1 dataset

Motif DE_60h DE_60h-NFATC4_MA1525.3 9 bp overlap

NIPBL 3 datasets

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 112 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 134 bp overlap

ChIP hESC_activin GSE64758.NIPBL.hESC_activin 123 bp overlap

NR2C2 3 datasets

Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap

Motif DE_60h DE_60h-NR2C2_MA0504.2 14 bp overlap

Motif DE_72h DE_72h-NR2C2_MA0504.2 14 bp overlap

NR2F1 3 datasets

Motif DE_48h DE_48h-NR2F1_MA1537.2 13 bp overlap

Motif DE_60h DE_60h-NR2F1_MA1537.2 13 bp overlap

Motif DE_72h DE_72h-NR2F1_MA1537.2 13 bp overlap

Nfat5 1 dataset

Motif DE_60h DE_60h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 1 dataset

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 1 dataset

Motif DE_60h DE_60h-Nfatc2_MA0152.3 8 bp overlap

Nobox 1 dataset

Motif DE_72h DE_72h-Nobox_MA0125.2 6 bp overlap

Nr2F6 2 datasets

Motif DE_60h DE_60h-Nr2F6_MA0728.1 15 bp overlap

Motif DE_72h DE_72h-Nr2F6_MA0728.1 15 bp overlap

Motif DE_72h DE_72h-PAX3_MA0780.1 10 bp overlap

POU5F1 15 datasets

ChIP BG03 GSE21614.POU5F1.BG03 71 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 249 bp overlap

ChIP GM23338 ENCFF333SNB 142 bp overlap

ChIP H1 ENCFF698ZAP 89 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 517 bp overlap

ChIP OSKM GSE81899.POU5F1.OSKM 235 bp overlap

ChIP WA01 ENCSR000BMU.POU5F1.WA01 88 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 64 bp overlap

ChIP WA09 GSE105028.POU5F1.WA09 90 bp overlap

ChIP WA09_heat-shock GSE105028.POU5F1.WA09_heat-shock 166 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 60 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 196 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 187 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 184 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 85 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 420 bp overlap

PPARD 3 datasets

Motif DE_48h DE_48h-PPARD_MA1550.2 14 bp overlap

Motif DE_60h DE_60h-PPARD_MA1550.2 14 bp overlap

Motif DE_72h DE_72h-PPARD_MA1550.2 14 bp overlap

Motif DE_72h DE_72h-Pax7_MA0680.3 10 bp overlap

Pparg::Rxra 3 datasets

Motif DE_48h DE_48h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_60h DE_60h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_72h DE_72h-PpargRxra_MA0065.3 13 bp overlap

RARA 2 datasets

Motif DE_60h DE_60h-RARA_MA0729.1 18 bp overlap

Motif DE_72h DE_72h-RARA_MA0729.1 18 bp overlap

Motif DE_72h DE_72h-RAX_MA0718.2 6 bp overlap

RELA 11 datasets

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 53 bp overlap

ChIP aortic-endothelial-cell_IL1B_D14 GSE139377.RELA.aortic-endothelial-cell_IL1B_D14 149 bp overlap

ChIP aortic-endothelial-cell_IL1B_D16 GSE139377.RELA.aortic-endothelial-cell_IL1B_D16 95 bp overlap

ChIP aortic-endothelial-cell_IL1B_D21 GSE139377.RELA.aortic-endothelial-cell_IL1B_D21 70 bp overlap

ChIP aortic-endothelial-cell_IL1B_D25 GSE139377.RELA.aortic-endothelial-cell_IL1B_D25 110 bp overlap

ChIP aortic-endothelial-cell_IL1B_D28 GSE139377.RELA.aortic-endothelial-cell_IL1B_D28 68 bp overlap

ChIP aortic-endothelial-cell_IL1B_D38 GSE139377.RELA.aortic-endothelial-cell_IL1B_D38 68 bp overlap

ChIP aortic-endothelial-cell_IL1B_D40 GSE139377.RELA.aortic-endothelial-cell_IL1B_D40 135 bp overlap

ChIP aortic-endothelial-cell_IL1B_D47 GSE139377.RELA.aortic-endothelial-cell_IL1B_D47 145 bp overlap

ChIP aortic-endothelial-cell_IL1B_D49 GSE139377.RELA.aortic-endothelial-cell_IL1B_D49 210 bp overlap

ChIP aortic-endothelial-cell_IL1B_D7 GSE139377.RELA.aortic-endothelial-cell_IL1B_D7 121 bp overlap

Motif DE_60h DE_60h-RORA_MA0072.2 11 bp overlap

Motif DE_60h DE_60h-RORB_MA1150.2 10 bp overlap

Motif DE_60h DE_60h-RORC_MA1151.2 10 bp overlap

Rarb 2 datasets

Motif DE_60h DE_60h-Rarb_MA0857.1 16 bp overlap

Motif DE_72h DE_72h-Rarb_MA0857.1 16 bp overlap

Rarg 2 datasets

Motif DE_60h DE_60h-Rarg_MA0859.2 15 bp overlap

Motif DE_72h DE_72h-Rarg_MA0859.2 15 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 355 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 348 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 223 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 186 bp overlap

SMAD2_3 7 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 174 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 219 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 203 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 454 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 315 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 326 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 342 bp overlap

SMAD3 3 datasets

ChIP BG03 GSE21614.SMAD3.BG03 246 bp overlap

ChIP HCC1954 GSE104760.SMAD3.HCC1954 243 bp overlap

ChIP HCC1954_TGFb GSE104760.SMAD3.HCC1954_TGFb 80 bp overlap

SMARCA4 1 dataset

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 204 bp overlap

SMARCC1 3 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 306 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 184 bp overlap

ChIP ESC S25-ESC-d0-BAF155-exp1 522 bp overlap

SMARCE1 1 dataset

ChIP HMLE-Twist-ER_125nM_4OHT GSE96933.SMARCE1.HMLE-Twist-ER_125nM_4OHT 185 bp overlap

ChIP HCAEC GSE101921.SMC1.HCAEC 278 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 224 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 929 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 191 bp overlap

ChIP K562 ENCFF059YCJ 105 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 127 bp overlap

Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap

Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

STAT3 1 dataset

ChIP HCC70_EtOH GSE85579.STAT3.HCC70_EtOH 78 bp overlap

Smad4 3 datasets

Motif DE_48h DE_48h-Smad4_MA1153.2 7 bp overlap

Motif DE_60h DE_60h-Smad4_MA1153.2 7 bp overlap

Motif DE_72h DE_72h-Smad4_MA1153.2 7 bp overlap

Sox6 3 datasets

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap

Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 211 bp overlap

ChIP NPC GSE154479.TCF3.NPC 387 bp overlap

TEAD1 3 datasets

Motif DE_60h DE_60h-TEAD1_MA0090.4 9 bp overlap

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

ChIP HUCCT1 GSE68296.TEAD1.HUCCT1 66 bp overlap

TEAD2 2 datasets

Motif DE_60h DE_60h-TEAD2_MA1121.2 7 bp overlap

Motif DE_72h DE_72h-TEAD2_MA1121.2 7 bp overlap

TEAD3 2 datasets

Motif DE_60h DE_60h-TEAD3_MA0808.1 8 bp overlap

Motif DE_72h DE_72h-TEAD3_MA0808.1 8 bp overlap

TEAD4 5 datasets

Motif DE_60h DE_60h-TEAD4_MA0809.3 8 bp overlap

Motif DE_72h DE_72h-TEAD4_MA0809.3 8 bp overlap

ChIP ESC S26-ESC-d0-TEAD4-exp1 338 bp overlap

ChIP ESC S26-ESC-d0-TEAD4-exp1 329 bp overlap

ChIP hESC GSE99202.TEAD4.hESC 93 bp overlap

ChIP HUVEC-C GSE88894.TFEB.HUVEC-C 166 bp overlap

THRB 3 datasets

Motif DE_48h DE_48h-THRB_MA1574.2 13 bp overlap

Motif DE_60h DE_60h-THRB_MA1574.2 13 bp overlap

Motif DE_72h DE_72h-THRB_MA1574.2 13 bp overlap

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 85 bp overlap

TRIM28 2 datasets

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 273 bp overlap

ChIP hESC GSE115387.TRIM28.hESC 379 bp overlap

USF1 3 datasets

ChIP H1 ENCFF090WVU 118 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 346 bp overlap

ChIP WTC11 ENCFF699QGS 189 bp overlap

ChIP WTC11 ENCFF139JAW 229 bp overlap

VENTX 1 dataset

Motif DE_72h DE_72h-VENTX_MA0724.1 9 bp overlap

Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap

ZNF148 2 datasets

Motif DE_48h DE_48h-ZNF148_MA1653.2 10 bp overlap

Motif DE_72h DE_72h-ZNF148_MA1653.2 10 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 254 bp overlap

ZNF281 2 datasets

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap

ZNF324 1 dataset

Motif DE_60h DE_60h-ZNF324_MA1977.2 14 bp overlap

ZNF462 3 datasets

ChIP GM23338 ENCFF896CCA 251 bp overlap

ChIP GM23338 ENCFF896CCA 215 bp overlap

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 178 bp overlap

ZNF530 3 datasets

Motif DE_48h DE_48h-ZNF530_MA1981.2 14 bp overlap

Motif DE_60h DE_60h-ZNF530_MA1981.2 14 bp overlap

Motif DE_72h DE_72h-ZNF530_MA1981.2 14 bp overlap

ZNF684 2 datasets

Motif DE_60h DE_60h-ZNF684_MA1600.2 14 bp overlap

Motif DE_72h DE_72h-ZNF684_MA1600.2 14 bp overlap

ZNF700 1 dataset

ChIP K562 ENCFF657OXY 305 bp overlap

ZNF766 1 dataset

ChIP K562 ENCFF348LDO 495 bp overlap

ZNF784 1 dataset

Motif DE_60h DE_60h-ZNF784_MA1717.2 8 bp overlap

ZSCAN4 1 dataset

ChIP HEK293 ENCSR211GNP.ZSCAN4.HEK293 468 bp overlap

Zfp335 2 datasets

Motif DE_60h DE_60h-Zfp335_MA2002.2 7 bp overlap

Motif DE_72h DE_72h-Zfp335_MA2002.2 7 bp overlap