The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for RORA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RORA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RORA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:60,397,071–60,398,286 | 831.2 kb | Distal (>10kb) Multiome | 627 | |
| chr15:60,398,426–60,398,937 | 830.6 kb | Distal (>10kb) Multiome | 531 | |
| chr15:60,478,648–60,479,679 | 750.1 kb | Distal (>10kb) Multiome | 975 | |
| chr15:60,591,104–60,593,374 | 636.6 kb | Distal (>10kb) Multiome | 802 | |
| chr15:60,614,824–60,615,950 | 613.8 kb | Distal (>10kb) Multiome | 252 | |
| chr15:60,845,776–60,846,719 | 383.1 kb | Distal (>10kb) Multiome | 52 | |
| chr15:60,858,558–60,859,431 | 370.2 kb | Distal (>10kb) Multiome | 55 | |
| chr15:60,976,429–60,976,888 | 252.7 kb | Distal (>10kb) Multiome | 28 | |
| chr15:61,227,530–61,227,838 | 1.4 kb | Proximal (<10kb) | 158 | |
| chr15:61,228,786–61,229,864 | 60 bp | At TSS Multiome | 220 | |
| chr15:61,232,209–61,232,647 | 3.0 kb | Proximal (<10kb) | 21 | |
| chr15:61,364,672–61,365,410 | 135.9 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the RORA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.