METTL17

methyltransferase like 17 | FLJ20859, METT11D1

Enables 4 iron, 4 sulfur cluster binding activity. Involved in mitochondrial small ribosomal subunit assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 17 terms

4 iron, 4 sulfur cluster binding (GO:0051539)S-adenosyl-L-methionine binding (GO:1904047)S-adenosyl-L-methionine binding (GO:1904047)intracellular organelle lumen (GO:0070013)methyltransferase activity (GO:0008168)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial ribosome binding (GO:0097177)mitochondrial small ribosomal subunit assembly (GO:0180026)mitochondrion (GO:0005739)nucleoplasm (GO:0005654)protein binding (GO:0005515)ribosomal small subunit biogenesis (GO:0042274)ribosomal small subunit biogenesis (GO:0042274)small molecule binding (GO:0036094)translation (GO:0006412)

Expression (TPM)

TFs regulating METTL17 0 TFs

Transcription factors with Perturb-seq knockdown data for METTL17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to METTL17

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:20,705,982–20,707,066	283.6 kb	Distal (>10kb) Multiome	110
chr14:20,732,350–20,732,945	257.4 kb	Distal (>10kb) Multiome	51
chr14:20,815,630–20,816,752	173.9 kb	Distal (>10kb) Multiome	75
chr14:20,820,324–20,820,826	169.4 kb	Distal (>10kb) Multiome	204
chr14:20,970,757–20,971,991	18.5 kb	Distal (>10kb) Multiome	745
chr14:20,989,595–20,990,562	107 bp	At TSS Multiome	835
chr14:20,998,842–20,999,321	8.8 kb	Proximal (<10kb)	125
chr14:21,024,660–21,026,214	35.1 kb	Distal (>10kb) Multiome	768
chr14:21,069,280–21,071,963	81.6 kb	Distal (>10kb) Multiome	899
chr14:21,092,184–21,093,275	102.7 kb	Distal (>10kb) Multiome	774
chr14:21,094,184–21,094,833	104.5 kb	Distal (>10kb) Multiome	210
chr14:21,097,193–21,098,877	108.5 kb	Distal (>10kb) Multiome	469
chr14:21,103,222–21,104,876	114.0 kb	Distal (>10kb) Multiome	1128
chr14:21,191,911–21,192,845	202.1 kb	Distal (>10kb) Multiome	463
chr14:21,268,822–21,270,154	279.7 kb	Distal (>10kb) Multiome	1029

Genome Browser

Genomic view of the METTL17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.