This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNASE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:20,609,147–20,610,547 | 192.7 kb | Distal (>10kb) Multiome | 852 | |
| chr14:20,612,915–20,614,464 | 189.2 kb | Distal (>10kb) Multiome | 1003 | |
| chr14:20,624,684–20,626,122 | 177.5 kb | Distal (>10kb) Multiome | 728 | |
| chr14:20,630,325–20,631,286 | 172.1 kb | Distal (>10kb) Multiome | 507 | |
| chr14:20,631,700–20,633,862 | 169.7 kb | Distal (>10kb) Multiome | 757 | |
| chr14:20,642,696–20,643,499 | 159.8 kb | Distal (>10kb) Multiome | 52 | |
| chr14:20,644,459–20,645,301 | 158.1 kb | Distal (>10kb) Multiome | 52 | |
| chr14:20,652,905–20,654,391 | 149.5 kb | Distal (>10kb) Multiome | 320 | |
| chr14:20,657,425–20,658,132 | 145.1 kb | Distal (>10kb) Multiome | 320 | |
| chr14:20,662,835–20,663,940 | 139.6 kb | Distal (>10kb) Multiome | 587 | |
| chr14:20,681,216–20,685,294 | 118.4 kb | Distal (>10kb) Multiome | 1181 | |
| chr14:20,705,982–20,707,066 | 96.5 kb | Distal (>10kb) Multiome HiCAR | 110 | |
| chr14:20,732,350–20,732,945 | 70.2 kb | Distal (>10kb) Multiome HiCAR | 51 | |
| chr14:20,794,899–20,795,256 | 7.6 kb | Proximal (<10kb) | 45 | |
| chr14:20,815,630–20,816,752 | 13.3 kb | Distal (>10kb) Multiome | 75 | |
| chr14:20,820,324–20,820,826 | 17.7 kb | Distal (>10kb) Multiome | 204 | |
| chr14:20,970,757–20,971,991 | 168.6 kb | Distal (>10kb) Multiome | 745 | |
| chr14:20,989,595–20,990,562 | 187.0 kb | Distal (>10kb) Multiome | 835 | |
| chr14:21,024,660–21,026,214 | 222.3 kb | Distal (>10kb) Multiome | 768 | |
| chr14:21,069,280–21,071,963 | 268.8 kb | Distal (>10kb) Multiome | 899 | |
| chr14:21,092,184–21,093,275 | 289.9 kb | Distal (>10kb) Multiome | 774 | |
| chr14:21,094,184–21,094,833 | 291.6 kb | Distal (>10kb) Multiome | 210 | |
| chr14:21,097,193–21,098,877 | 295.6 kb | Distal (>10kb) Multiome | 469 |
Genomic view of the RNASE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.