The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for RNASE4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASE4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASE4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:20,412,688–20,413,758 | 271.2 kb | Distal (>10kb) Multiome | 865 | |
| chr14:20,454,384–20,455,825 | 229.5 kb | Distal (>10kb) Multiome | 1012 | |
| chr14:20,460,777–20,462,259 | 222.9 kb | Distal (>10kb) Multiome | 995 | |
| chr14:20,468,846–20,470,856 | 215.2 kb | Distal (>10kb) Multiome | 950 | |
| chr14:20,494,584–20,495,486 | 189.5 kb | Distal (>10kb) Multiome | 201 | |
| chr14:20,609,147–20,610,547 | 74.4 kb | Distal (>10kb) Multiome | 852 | |
| chr14:20,612,915–20,614,464 | 70.9 kb | Distal (>10kb) Multiome | 1003 | |
| chr14:20,624,684–20,626,122 | 59.2 kb | Distal (>10kb) Multiome | 728 | |
| chr14:20,630,325–20,631,286 | 53.8 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr14:20,631,700–20,633,862 | 51.4 kb | Distal (>10kb) Multiome HiCAR | 757 | |
| chr14:20,642,696–20,643,499 | 41.6 kb | Distal (>10kb) Multiome | 52 | |
| chr14:20,644,459–20,645,301 | 39.8 kb | Distal (>10kb) Multiome | 52 | |
| chr14:20,652,905–20,654,391 | 31.2 kb | Distal (>10kb) Multiome HiCAR | 320 | |
| chr14:20,657,425–20,658,132 | 26.8 kb | Distal (>10kb) Multiome HiCAR | 320 | |
| chr14:20,662,835–20,663,940 | 21.3 kb | Distal (>10kb) Multiome | 587 | |
| chr14:20,681,216–20,685,294 | 143 bp | At TSS Multiome | 1181 | |
| chr14:20,691,096–20,691,328 | 6.5 kb | Proximal (<10kb) | 285 | |
| chr14:20,705,982–20,707,066 | 21.8 kb | Distal (>10kb) Multiome | 110 | |
| chr14:20,732,350–20,732,945 | 48.1 kb | Distal (>10kb) Multiome | 51 | |
| chr14:20,815,630–20,816,752 | 131.6 kb | Distal (>10kb) Multiome | 75 | |
| chr14:20,970,757–20,971,991 | 286.9 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the RNASE4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.