PIP4P1

phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 | MGC26684, C14orf9, TMEM55B

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

Member of: DE-7 DE-7.8

Biological processes 29 terms

cholesterol metabolic process (GO:0008203)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosome localization (GO:0032418)nucleoplasm (GO:0005654)phagocytic vesicle membrane (GO:0030670)phagocytic vesicle membrane (GO:0030670)phagocytic vesicle membrane (GO:0030670)phosphatidylinositol dephosphorylation (GO:0046856)phosphatidylinositol dephosphorylation (GO:0046856)phosphatidylinositol dephosphorylation (GO:0046856)phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity (GO:0034597)phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity (GO:0034597)phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity (GO:0034597)phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity (GO:0034597)phospholipid metabolic process (GO:0006644)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of TORC1 signaling (GO:1904263)protein binding (GO:0005515)proton-transporting V-type ATPase complex assembly (GO:0070070)regulation of signal transduction by p53 class mediator (GO:1901796)response to sterol depletion (GO:0006991)

Expression (TPM)

TFs regulating PIP4P1 0 TFs

Transcription factors with Perturb-seq knockdown data for PIP4P1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIP4P1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PIP4P1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIP4P1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:20,332,742–20,333,665	128.2 kb	Distal (>10kb) Multiome	694
chr14:20,342,187–20,344,100	118.1 kb	Distal (>10kb) Multiome	1112
chr14:20,412,688–20,413,758	48.1 kb	Distal (>10kb) Multiome	865
chr14:20,454,384–20,455,825	6.3 kb	Proximal (<10kb) Multiome	1012
chr14:20,460,777–20,462,259	222 bp	At TSS Multiome	995
chr14:20,468,846–20,470,856	8.0 kb	Proximal (<10kb) Multiome	950
chr14:20,494,584–20,495,486	33.6 kb	Distal (>10kb) Multiome	201
chr14:20,609,147–20,610,547	148.7 kb	Distal (>10kb) Multiome HiCAR	852
chr14:20,612,915–20,614,464	152.2 kb	Distal (>10kb) Multiome	1003
chr14:20,624,684–20,626,122	163.9 kb	Distal (>10kb) Multiome	728
chr14:20,630,325–20,631,286	169.3 kb	Distal (>10kb) Multiome	507
chr14:20,631,700–20,633,862	171.8 kb	Distal (>10kb) Multiome	757
chr14:20,642,696–20,643,499	181.6 kb	Distal (>10kb) Multiome	52
chr14:20,644,459–20,645,301	183.4 kb	Distal (>10kb) Multiome	52
chr14:20,652,905–20,654,391	191.9 kb	Distal (>10kb) Multiome	320
chr14:20,657,425–20,658,132	196.4 kb	Distal (>10kb) Multiome	320
chr14:20,662,835–20,663,940	201.9 kb	Distal (>10kb) Multiome	587
chr14:20,681,216–20,685,294	223.0 kb	Distal (>10kb) Multiome	1181
chr14:20,705,982–20,707,066	245.0 kb	Distal (>10kb) Multiome	110
chr14:20,732,350–20,732,945	271.2 kb	Distal (>10kb) Multiome	51

Genome Browser

Genomic view of the PIP4P1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.