TEP1

telomerase associated protein 1 | TLP1, TP1, TROVE1, VAULT2, p240

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Developmental clusters: GC2

Biological processes 24 terms

DNA metabolic process (GO:0006259)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA-templated DNA biosynthetic process (GO:0006278)chromosome, telomeric region (GO:0000781)cytoplasm (GO:0005737)enzyme binding (GO:0019899)nuclear matrix (GO:0016363)nucleus (GO:0005634)p53 binding (GO:0002039)protein binding (GO:0005515)protein transport (GO:0015031)ribonucleoprotein complex (GO:1990904)telomerase RNA binding (GO:0070034)telomerase RNA binding (GO:0070034)telomerase RNA binding (GO:0070034)telomerase activity (GO:0003720)telomerase activity (GO:0003720)telomerase activity (GO:0003720)telomerase holoenzyme complex (GO:0005697)telomerase holoenzyme complex (GO:0005697)telomerase holoenzyme complex (GO:0005697)telomere maintenance via recombination (GO:0000722)telomere maintenance via recombination (GO:0000722)

Expression (TPM)

TFs regulating TEP1 0 TFs

Transcription factors with Perturb-seq knockdown data for TEP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TEP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:20,332,742–20,333,665	80.2 kb	Distal (>10kb) Multiome	694
chr14:20,342,187–20,344,100	70.1 kb	Distal (>10kb) Multiome	1112
chr14:20,412,688–20,413,758	89 bp	At TSS Multiome	865
chr14:20,413,885–20,414,042	456 bp	At TSS	157
chr14:20,415,836–20,416,073	2.4 kb	Proximal (<10kb)	175
chr14:20,454,384–20,455,825	41.7 kb	Distal (>10kb) Multiome	1012
chr14:20,460,777–20,462,259	48.2 kb	Distal (>10kb) Multiome	995
chr14:20,468,846–20,470,856	56.0 kb	Distal (>10kb) Multiome	950
chr14:20,494,584–20,495,486	81.6 kb	Distal (>10kb) Multiome	201
chr14:20,609,147–20,610,547	196.7 kb	Distal (>10kb) Multiome HiCAR	852
chr14:20,612,915–20,614,464	200.2 kb	Distal (>10kb) Multiome HiCAR	1003
chr14:20,624,684–20,626,122	211.9 kb	Distal (>10kb) Multiome	728
chr14:20,630,325–20,631,286	217.3 kb	Distal (>10kb) Multiome	507
chr14:20,631,700–20,633,862	219.8 kb	Distal (>10kb) Multiome	757
chr14:20,642,696–20,643,499	229.6 kb	Distal (>10kb) Multiome	52
chr14:20,644,459–20,645,301	231.4 kb	Distal (>10kb) Multiome	52
chr14:20,652,905–20,654,391	239.9 kb	Distal (>10kb) Multiome	320
chr14:20,657,425–20,658,132	244.4 kb	Distal (>10kb) Multiome	320
chr14:20,662,835–20,663,940	249.9 kb	Distal (>10kb) Multiome	587
chr14:20,681,216–20,685,294	271.0 kb	Distal (>10kb) Multiome	1181
chr14:20,705,982–20,707,066	293.0 kb	Distal (>10kb) Multiome	110

Genome Browser

Genomic view of the TEP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.